In this study, a new, effective and environmentally benign procedure for the synthesis of
dihydropyrimidinone and thione derivatives with various benzaldehydes, urea or thiourea, and ethyl
acetoacetate in the presence of 1,4-diazabicyclo[2.2.2]octanium diacetate as a novel acidic ionic liquid,
in high yield and short reaction time is reported. This method provides several advantages such as easy
work-up, green, environmental friendliness and fast reaction condition along with high yields.
Keywords: Biginelli reaction, ethyl acetoacetate, ionic liquid, solvent free, thiourea, urea.
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