Biofilm development is a survival strategy for majority of bacteria to adapt
to their living environment. These biofilms are prevalent on most surfaces in nature.
Microbial cells in biofilm exhibit significantly enhanced tolerance and resistance to
antimicrobial challenge and host defenses. Therefore, the control and eradication of
biofilm-associated diseases present a great challenge. Recently, there is considerable biomedical incentive in the
development of nanoparticles with self-antibacterial activity or as antibiotic carriers. The advantages of coatings
incorporating different types of nano-agents for antimicrobial surface generation are here reviewed. Although the main
coatings currently used or investigated and the associated synthesis processes are individually described, emphasis is
made on silver-loaded mesoporous thin coatings. Recent developments suggest that mesoporous oxide thin films
(especially titania) incorporating metal nanoparticles is becoming a prime candidate for antimicrobial coatings.
Keywords: Antimicrobial coating, self-antibacterial nanoparticles, antibiotic carriers, nanocomposite, mesoporous films,
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