Photothermal Ablation of Cancer Cells Using Folate-Coated Gold/ Graphene Oxide Composite

Author(s): Nicolò Mauro, Anna Li Volsi, Cinzia Scialabba, Mariano Licciardi, Gennara Cavallaro, Gaetano Giammona

Journal Name: Current Drug Delivery

Volume 14 , Issue 3 , 2017

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Abstract:

Objective: A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells.

Methods: The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-folate conjugate. Paclitaxel was loaded by sonication. The hybrid was characterized by UV-Vis spectroscopy, DSC analysis and SEM microscopy. The cytotoxicity, thermoablation and anticancer activity were evaluated in vitro on MCF-7 and 16 HBE.

Results: In vitro tests showed that the paclitaxel-loaded hybrid improved the effectiveness of the drug especially after photothermal treatments.

Conclusion: On the whole, while gold/graphene composite provided an excellent time-dependent photothermal effect, the loading of paclitaxel allowed a suitable chemotherapy, thus killing cancer cells both via a selective laser beam thermoablation and hyperthermia-triggered chemotherapy.

Keywords: Gold nanoparticles, graphene, hyperthermia, inulin, folate, paclitaxel, thermal ablation.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2017
Published on: 28 April, 2017
Page: [433 - 443]
Pages: 11
DOI: 10.2174/1567201813666160520113804
Price: $65

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