The Role of Tumor Associated Macrophages in the Tumor Microenvironment: Mechanism and Functions

Author(s): Jie Zhu, Qiaoming Zhi, Binhua P. Zhou, Min Tao, Jingyi Liu, Wei Li

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 16 , Issue 9 , 2016

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


During tumor progression, several types of inflammatory cells are recruited into the tumor site, where they participate in tumor-associated inflammation, such as fibroblasts, granulocytes, lymphocytes and macrophages. Macrophages infiltrating into the tumor microenvironment are termed tumorassociated macrophages (TAMs). In response to multiple stimuli, macrophages undergo recruitment and polarization, and play an important role in further tumor development. In this article, we present a review of the mechanism of macrophage’ recruitment, and the role that TAMs play in promoting immunosuppression, tumor progress and metastasis, as well as chemoresistance and future therapeutic strategies.

Keywords: Tumor associated macrophages, tumor microenvironment, pancreatic cancer, breast cancer, lung cancer, lymphoma.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Published on: 15 August, 2016
Page: [1133 - 1141]
Pages: 9
DOI: 10.2174/1871520616666160520112622
Price: $65

Article Metrics

PDF: 203
HTML: 23
PRC: 1