Obstructive Sleep Apnea Syndrome: An Emerging Risk Factor for Dementia

Author(s): Laura Buratti, Simona Luzzi, Cristina Petrelli, Sara Baldinelli, Giovanna Viticchi, Leandro Provinciali, Claudia Altamura, Fabrizio Vernieri, Mauro Silvestrini

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 15 , Issue 6 , 2016

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Graphical Abstract:


Epidemiological studies have suggested that obstructive sleep apnea syndrome (OSAS) may increase the risk of developing cognitive impairment. In patients with Alzheimer’s disease (AD), the prevalence of OSAS is much higher than that expected in cognitively healthy subjects. A deeper knowledge of the pathophysiological link between OSAS and AD and the demonstration that OSAS may directly influence the development of cognitive alterations, would increase prevention and treatment strategies for AD patients. In this article, we discuss the evidence of the association between OSAS and dementia. Moreover, we present data about the functional and anatomic cerebral changes induced by OSAS and the possible effects on cognitive activities and on AD pathogenesis. The possibility to positively influence cognitive impairment by OSAS treatment will be also discussed.

Keywords: Alzheimer’s disease, cognitive deterioration, continuous positive airway pressure, obstructive sleep apnea syndrome, pathophysiology, preventive strategies.

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Article Details

Year: 2016
Page: [678 - 682]
Pages: 5
DOI: 10.2174/1871527315666160518123930
Price: $65

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