MicroRNAs (miRNAs) are a class of post-transcriptional gene expression modulators. In
the past two decades, over 1500 human miRNAs were discovered. These small non-coding RNAs
regulate various biological processes, including cell growth, proliferation, differentiation, and cell
death. Thus, miRNAs have been proposed as new therapeutical agents in different multifactorial diseases
such as cancer. Since miRNAs therapies represent a great promise, many research studies have
been focused on the development of delivery strategies to overcome miRNAs biopharmaceutical issues.
Lipid delivery systems are undoubtedly the non-viral carriers most largely investigated due to
their biocompatibility, biodegradability, easy production, low toxicity and immunogenicity, possibility to easily modify
the carriers for targeting strategies. In this mini-review we provide a rapid and updated overview on the lipid delivery system
currently used to deliver miRNAs, pointing out the progresses achieved in the optimization of these nanovectors,
which led up to the first clinical trial.