Background: The development of drugs capable of enhance or inhibit
the cell proliferation is an area in expansion at modern biomedical sciences. Recent
researches have shown that latex has strong angiogenic potential.
Methods: We performed a bibliometric analysis on the global literature trying to identify: the main
scientometrics data, the botanical families and species, the angiogenic or antiangiogenic properties
and also discussed the results obtained on this topic up to now.
Results: The different bibliometric approaches, showed a continuous increase of both quantitative
and qualitative parameters in the studies of latex utilization in the angiogenesis process. From more
than 35,000 lactiferous species existing only 29 have been studied and showed angiogenic potential.
Then, the potential for finding new therapeutic compounds in latex is a new and promising field that
needs to be better explored. Regarding the biological activity, 59% of articles have reported the angiogenic
activity and 41% the antiangiogenic property. The most articles identified in this research,
have been used in their experimental analysis the crude latex (73.41%). Only 26.52% of the articles
used biocompounds isolated from latex. Among the weaknesses in this field, it is necessary to point:
the molecular characterization of latex; the establishment of molecular mechanism of action; and
demonstration of latex biocompunds safety and effectiveness in clinical trials.
Conclusion: Those results are important to spread knowledge about the use of latex as a new biomaterial
employed in medicine, indicate trends, point out the technical difficult on the development
of new drugs.