Background: The use of microwave irradiation is an important development for the synthesis
of benzimidazoles in the 21st century, and in recent years, microwave-assisted heterocyclic synthesis
has gained significant attention in modern drug discovery studies. Benzimidazoles are an important
group in the field of medicinal chemistry because of a wide range of biological activities. This review
article provides a collection of studies on the synthesis of benzimidazole derivatives by microwave
techniques over a twenty-one years period for an alternative to conventional heating.
Methods: Microwave irradiation has been applied for the synthesis of benzimidazoles. The most used
method for the preparation of benzimidazoles is condensation of o-diaminobenzene with carboxylic
acids or derivatives.
Results: Benzimidazoles have a seminal role in drug discovery and these derivatives show an excellent
scaffold for the development of novel drugs, polymers, ligands and dys. Microwave heating is a useful
technique for the synthesis of benzimidazole derivatives. When compared to the conventional heating
methods, many advantages, such as reduction in reaction times, greater yield and purity provision, and
less energy requirement, and creation of environmentally friendly conditions have been noted.
Conclusion: This review aimed to demonstrate the applications of microwave for the synthesis of benzimidazole
and their derivatives from 1994-2016. Microwave-assisted heterocyclic synthesis is a
method that can be used to quickly explore and increase diversity in modern chemistry. In the light of
the these studies, it could be argued that nearly all of the previously conventionally heated reactions
could be performed using the microwave heating. We hope that this review will be helpful to synthesize
new potential bioactive benzimidazole derivatives by using this effective method. Time is a very important
dimension for researches people. If you save time, you can research much more. In this respect, the
microwave technique helps researchers to make effective studies.