Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape

Author(s): Kenneth Blum, Marcelo Febo, Rajendra D. Badgaiyan, Zsolt Demetrovics, Thomas Simpatico, Claudia Fahlke, Oscar-Berman M., Mona Li, Kristina Dushaj, Mark S. Gold

Journal Name: Current Neuropharmacology

Volume 15 , Issue 1 , 2017

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Graphical Abstract:


Background: In 1990, Blum and associates provided the first confirmed genetic link between the DRD2 polymorphisms and alcoholism. This finding was based on an earlier conceptual framework, which served as a blueprint for their seminal genetic association discovery they termed “Brain Reward Cascade.” These findings were followed by a new way of understanding all addictive behaviors (substance and non-substance) termed “Reward Deficiency Syndrome” (RDS). RDS incorporates a complex multifaceted array of inheritable behaviors that are polygenic.

Objective: In this review article, we attempt to clarify these terms and provide a working model to accurately diagnose and treat these unwanted behaviors.

Method: We are hereby proposing the development of a translational model we term "Reward Deficiency Solution System™" that incorporates neurogenetic testing and meso-limbic manipulation of a "hypodopaminergic" trait/state, which provides dopamine agonistic therapy (DAT) as well as reduced "dopamine resistance," while embracing "dopamine homeostasis."

Result: The result is better recovery and relapse prevention, despite DNA antecedents, which could impact the recovery process and relapse. Understanding the commonality of mental illness will transform erroneous labeling based on symptomatology, into a genetic and anatomical etiology. WC: 184.

Keywords: Dopamine homeostasis, genetics, reward deficiency solution system, Reward Deficiency Syndrome (RDS).

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Article Details

Year: 2017
Published on: 13 December, 2016
Page: [184 - 194]
Pages: 11
DOI: 10.2174/1570159X13666160512150918
Price: $65

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