Background: In 1990, Blum and associates provided the first confirmed
genetic link between the DRD2 polymorphisms and alcoholism. This finding was
based on an earlier conceptual framework, which served as a blueprint for their
seminal genetic association discovery they termed “Brain Reward Cascade.” These
findings were followed by a new way of understanding all addictive behaviors
(substance and non-substance) termed “Reward Deficiency Syndrome” (RDS). RDS
incorporates a complex multifaceted array of inheritable behaviors that are polygenic.
Objective: In this review article, we attempt to clarify these terms and provide a
working model to accurately diagnose and treat these unwanted behaviors.
Method: We are hereby proposing the development of a translational model we term "Reward Deficiency
Solution System™" that incorporates neurogenetic testing and meso-limbic manipulation of a
"hypodopaminergic" trait/state, which provides dopamine agonistic therapy (DAT) as well as reduced
"dopamine resistance," while embracing "dopamine homeostasis."
Result: The result is better recovery and relapse prevention, despite DNA antecedents, which could
impact the recovery process and relapse. Understanding the commonality of mental illness will transform
erroneous labeling based on symptomatology, into a genetic and anatomical etiology. WC: 184.