Medicinal Chemistry Perspective of Fused Isoxazole Derivatives

Author(s): Mahesh A. Barmade, Prashant R. Murumkar, Mayank Kumar Sharma, Mange Ram Yadav

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 26 , 2016

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Graphical Abstract:


Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide, the marketed drugs. This review article covers research articles reported till date covering biological activity along with SAR of fused isoxazole derivatives.

Keywords: Anticancer agents, Antidepressant agents, Antidiabetic agents, Antimicrobial agents, Benz-isoxazole, Fused isoxazole, Isoxazole, Tricyclic isoxazole.

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Article Details

Year: 2016
Published on: 06 May, 2016
Page: [2863 - 2883]
Pages: 21
DOI: 10.2174/1568026616666160506145700
Price: $65

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PDF: 67
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