Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best
combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five
membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the
marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant
for showing antipsychotic activity in risperidone and anticonvulsant activity in zonisamide,
the marketed drugs. This review article covers research articles reported till date covering biological
activity along with SAR of fused isoxazole derivatives.
Keywords: Anticancer agents, Antidepressant agents, Antidiabetic agents, Antimicrobial agents, Benz-isoxazole, Fused isoxazole,
Isoxazole, Tricyclic isoxazole.
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