Matrine: Bioactivities and Structural Modifications

Author(s): Jiulin Huang, Hui Xu

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 28 , 2016

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Graphical Abstract:


Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity, insecticidal activity, antimicrobial activity, etc. The present review has summarized the biological activities and structural modifications of matrine and its derivatives focused on their N-1 position and lactam ring from 2010 to 2015. In addition, the mechanism of action and structure-activity relationships of matrine and its derivatives are discussed.

Keywords: Matrine derivatives, Biological activities, Structural modifications, Mechanism of action, Structure-activity relationship, Sophora flavescens.

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Article Details

Year: 2016
Page: [3365 - 3378]
Pages: 14
DOI: 10.2174/1568026616666160506131012
Price: $65

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