Intracellular Ca2+ signal plays a major role in many cellular processes, such as
apoptosis and epithelial to mesenchymal transition (EMT). The role of Ca2+ in apoptotic
signaling has been investigated deeply over the past few decades. In recent years, it has made
progress in the interactions of intracellular Ca2+ homeostasis with EMT. Besides, Bcl-2 family
proteins as versatile regulators of cell apoptosis not only regulate Ca2+ signal, but also
play an important role in the induction of EMT. In this review, we summarized the relations
among intracellular Ca2+ concentration, apoptosis and Bcl-2 family proteins. We also discussed
the functions of intracellular Ca2+ concentration and Bcl-2 family proteins in EMT.
By taking into account these analyses; we proposed a hypothesis of cell death and survival
controlled by calcium signal.
Keywords: Calcium signal, apoptosis, epithelial to mesenchymal transition, EMT, Bcl-2 family proteins, cancer.
Rights & PermissionsPrintExport