Anticancer Activity and Modes of Action of (arene) ruthenium(II) Complexes Coordinated to C-, N-, and O-ligands

Author(s): Bernhard Biersack

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 16 , Issue 10 , 2016


Become EABM
Become Reviewer
Call for Editor

Abstract:

An overview of anticancer active (arene)ruthenium(II) complexes coordinated to period 2 element-based ligand systems, i.e., carbon-, nitrogen-, and oxygen-coordinated ligands, is provided in this mini-review. A bridge is forged from the large group of anticancer active ruthenium compounds with monodentate and chelating nitrogen ligands via complexes of O,O-chelating ligands to organometallic ruthenium derivatives coordinated to carbon. (Arene)ruthenium(II) complexes with reduced side-effects and enhanced efficacy against cancer are highlighted. Pertinent literature is covered up to 2014.

Keywords: Anticancer drugs, (Arene)Ru(II), DNA binding, Metastasis, Organometallic compounds, Ruthenium.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 16
ISSUE: 10
Year: 2016
Published on: 01 May, 2016
Page: [804 - 814]
Pages: 11
DOI: 10.2174/138955751610160503004623
Price: $65

Article Metrics

PDF: 46
HTML: 2
EPUB: 1
PRC: 1