Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition

Author(s): Pei-Yu Chen, Michael Simons

Journal Name: Current Drug Targets

Volume 17 , Issue 15 , 2016

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Abstract:

Endothelial to mesenchymal transition (EndMT) is a poorly understood phenomenon that results in normal endothelial cells acquiring a mesenchymal phenotype. EndMT has been observed in a number of pathological conditions, from cancer to fibrosis to cardiovascular disease and the process itself may play an important mechanistic role in the development of these disease states.

Keywords: Endothelial cell, endothelial to mesenchymal transition, EndMT, TGFβ, FGF.

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Article Details

VOLUME: 17
ISSUE: 15
Year: 2016
Page: [1707 - 1713]
Pages: 7
DOI: 10.2174/1389450117666160502151308
Price: $65

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