Title:MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases
VOLUME: 19 ISSUE: 5
Author(s):Haowei Li, Zanjing Zhai, Xinhua Qu, Jiake Xu, An Qin* and Kerong Dai*
Affiliation:Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, WA 6009, Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011
Keywords:Drug targets, miRNAs, osteoclasts, osteolytic diseases, bone homeostasis, biogenesis.
Abstract:Background: Understanding the roles of miRNAs in osteoclasts has great potential in the
diagnosis and treatment of osteolytic diseases.
Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and
summarize recent work on the roles of miRNAs in osteoclasts.
Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient
mechanism for the regulation of gene expression.
Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies
and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an
in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with
cognate genes will not be trivial, but fruitful.
