Abstract
Background: The survival of all biological systems depends on a series of complex pathways of maintenance and repair systems, which are the crucial components of the homeodynamic space of an individual. A progressive failure of maintenance and the consequent shrinkage of the homeodynamic space are the fundamental basis of ageing, age-related diseases and eventual death.
Mechanisms: Although longevity assurance genes do affect the essential lifespan of a species, there are no gerontogenes with the specific function to cause ageing and to limit the lifespan of an individual.
Approaches: Age-related diseases and other health problems may be better tackled by abandoning the futile hope of discovering the one-shot age-reversing or anti-ageing treatments. Developing realistic, practical and wholistic methods, such as mild stress-induced hormesis by physical, nutritional and mental hormetins, for maintaining health for a longer period are more likely to succeed.
Keywords: Homeodynamics, homeostasis, hormetics, hormesis, hormetin, longevity, stress.
Current Pharmacogenomics and Personalized Medicine
Title:Biological Basis of Ageing, Age-related Diseases and Interventions
Volume: 13 Issue: 2
Author(s): Suresh I. S. Rattan
Affiliation:
Keywords: Homeodynamics, homeostasis, hormetics, hormesis, hormetin, longevity, stress.
Abstract: Background: The survival of all biological systems depends on a series of complex pathways of maintenance and repair systems, which are the crucial components of the homeodynamic space of an individual. A progressive failure of maintenance and the consequent shrinkage of the homeodynamic space are the fundamental basis of ageing, age-related diseases and eventual death.
Mechanisms: Although longevity assurance genes do affect the essential lifespan of a species, there are no gerontogenes with the specific function to cause ageing and to limit the lifespan of an individual.
Approaches: Age-related diseases and other health problems may be better tackled by abandoning the futile hope of discovering the one-shot age-reversing or anti-ageing treatments. Developing realistic, practical and wholistic methods, such as mild stress-induced hormesis by physical, nutritional and mental hormetins, for maintaining health for a longer period are more likely to succeed.
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Cite this article as:
I. S. Rattan Suresh, Biological Basis of Ageing, Age-related Diseases and Interventions, Current Pharmacogenomics and Personalized Medicine 2015; 13 (2) . https://dx.doi.org/10.2174/1875692114999160502130603
DOI https://dx.doi.org/10.2174/1875692114999160502130603 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
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