Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants
in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly
growing number of natural compounds with neuro-protective effects have been described. Many efforts have been
made to explore the mechanisms for the neuro-protective properties of natural compounds. This review focuses on the
beneficial effects of natural products in treating traumatic brain injury (TBI). Numerous epidemiological studies have
shown consistent health benefits through the consumption of fruits, vegetables and nuts. In this review, we have summarized
the protective effects of natural compounds [apocynin, (-)-epigallocatechin Gallate (EGCG), baicalein, caffeic acid,
caffeic acid phenethyl ester, hydroxysaffloryellow A, osthole, oxy-resveratrol, pycnogenol, resveratrol, salvianolicacid B,
triptolide and wogonin], and omega-3 fatty acid, particularly docosahexaenoic acid and its metabolites, may be used as
personalized medicine against TBI and we have also discussed some of the barricades in translating these biofunctional
compounds into relevant therapeutics for TBI.
Conclusion: The benefits of natural products for traumatic brain injury show high inter-individual variability in their
therapeutic effects and thus, this article addresses the intersection between novel therapeutics for traumatic brain injury
and personalized medicine that will allow a broader range of interventions including the evidence-based natural products.