In silico Strategies to Probe Stereoselective Interactions of Multidrug Resistant Transporter P-glycoprotein

Author(s): Ishrat Jabeen.

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 8 , 2016

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Abstract:

ATP-dependent xenobiotic efflux transporter P-glycoprotein (P-gp) limits the cellular accumulation of many therapeutically important drug molecules. The most prominent of these are CNS active compounds and the potential chemotherapeutic agents. Co-administration of chemotherapeutic agents with modulators of P-glycoprotein has been advocated as a promising concept to circumvent drug resistance in tumor cells. Several pharmacoinformatics strategies to investigate ligand-P-glycoprotein interactions profiles revealed that these are promiscuous, multi-site and conformational dependent processes that take place in asymmetric 3D space within the binding cavity of P-gp. Therefore, avoiding stereoselectivity associated with ligand-protein interaction may compromise efficiency of the QSAR and other modeling strategies. Within this article, several SAR and QSAR strategies in combination with molecular docking studies on stereoisomeric inhibitors of P-gp will be highlighted to further explore the stereoselectivity of ligand-P-glycoprotein interaction.

Keywords: P-glycoprotein, MDR transporter, stereoselectivity, QSAR, pharmacophore, molecular docking.

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2016
Page: [824 - 832]
Pages: 9
DOI: 10.2174/1570180813999160429112620
Price: $65

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