Chronic lymphocytic leukemia (CLL), a clonal expansion of B CD5+
cells, is the most common type of adult leukemia in western countries. The accumulation
of neoplastic B-cells is primarily caused by prolonged life-span of these
cells due to deregulation of apoptosis, and only marginally due to a higher proliferation
rate. In spite of numerous reports characterizing particular mechanisms of
B-CLL cell apoptosis, still relatively little is known about the complex regulation
of this process. Therefore, more detailed research is required to understand the
complicated mechanisms and regulatory processes of apoptosis in neoplastic Blymphocytes.
Keywords: Apoptosis, B-cells, B-CLL, chronic lymphocytic leukemia, proliferation.
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