Background: Salvia species are used traditionally for treatment of many
disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally
used for treatment of inflammation, hypercholesterolemia, hemorrhoids and diarrhea.
Methods: In this study, antibacterial, antioxidant, toxicity, acetylcholinesterase and -
glucosidase inhibitory activities of several extracts of S. santolinifolia were evaluated.
Total phenol and flavonoid contents of the extracts were also determined.
Results: The MeOH extract showed high antioxidant activity in DPPH scavenging
and ferric reducing power assays. All samples exhibited high acetylcholinesterase
(IC50 = 42-89 g/ml) and -glucosidase inhibitory activities (IC50 = 24-174 g/ml).
The MeOH extract showed great antibacterial and antifungal activities especially against Bacillus cereus
and Candida albicans with MIC values from 10 to 200 g/ml.
Conclusion: Our findings indicated that S. santolinifolia is a rich source of natural compounds with
strong antimicrobial, antidiabetic and anti-Alzheimer activities. This plant has great potential for several
applications as pharmaceuticals and functional foods.