Opioids have been the mainstay for management of acute postoperative pain for several
decades. Extensive use, however, has been associated with multiple side effects. Multimodal approaches
that incorporate nonopioid medications and techniques have been observed to achieve optimum
pain control whilst decreasing side effects. Such strategies are particularly important to consider
for opioid-dependent and tolerant patients with various comorbidities undergoing different types of
surgery. This review assesses recent data on nonopioid analgesics for postoperative pain control, highlighting
evidence of their safety profiles in contemporary pain management.