Re-Examining the Need for Tissue Diagnosis in Pediatric Diffuse Intrinsic Pontine Gliomas: A Review

Author(s): Libby Kosnik Infinger, Charles B. Stevenson

Journal Name: Current Neuropharmacology

Volume 15 , Issue 1 , 2017

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Graphical Abstract:


Diffuse intrinsic pontine glioma (DIPG) is a malignant brain tumor of childhood that carries an extremely poor prognosis. There are ~200-300 new cases diagnosed each year, [1, 2] and little progress has been made in changing the prognosis and outcome of the tumor since it was first documented in the literature in 1926 [3]. The median overall survival is 8-11 months [4], with an overall survival rate of 30% at 1 year, and less than 10% at 2 years [4]. This review will provide background information on DIPGs, a historical look at the trends in caring for DIPG, and current trends in diagnosis and treatment. By changing the way we care for these terminal tumors, we can work towards having a better understanding of the underlying molecular biology, and attempt to develop better chemotherapeutic tools to combat the disease.

Keywords: Brainstem, brainstem glioma, DIPG, glioma, pediatric brain tumorm, pediatric neuro-oncology, pontine glioma, radio surgery.

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Article Details

Year: 2017
Page: [129 - 133]
Pages: 5
DOI: 10.2174/1570159X14666160425114024
Price: $65

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