Electrochemical Behavior of Melatonin and its Sensing in Pharmaceutical Formulations and in Human Urine

Author(s): Neeraj Kumar, Rajendra N. Goyal

Journal Name: Current Pharmaceutical Analysis

Volume 13 , Issue 1 , 2017


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Abstract:

Introduction: A simple, sensitive and reliable sensor has been explored for the determination of Melatonin (MEL) using cyclic voltammetry (CV) and square wave voltammetry (SWV).

Method: Irreversible oxidation of MEL was found to proceed through an adsorption controlled pathway at the glassy carbon electrode. The quantitative estimation of MEL was performed using SWV in a linear concentration range of 5-200 µM with a sensitivity of 0.0437 µM/ µA and a limit of detection of 0.3432 µM. The proposed protocol was also applied for determining MEL content in pharmaceutical samples and recovery studies in human urine samples were also performed.

Result: The observed results demonstrated a good agreement with the stated values.

Keywords: Melatonin, glassy carbon electrode, voltammetry, oxidation, human urine.

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2017
Published on: 24 November, 2016
Page: [85 - 90]
Pages: 6
DOI: 10.2174/1573412912666160422154459
Price: $65

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