The Molecular Recognition Paradigm of Environmental Chemicals with Biomacromolecules

Author(s): Wenjing Zhang, Liumeng Pan, Haifei Wang, Xuan Lv, Keke Ding

Journal Name: Current Protein & Peptide Science

Volume 18 , Issue 1 , 2017

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Graphical Abstract:


The interactions of ligands with biomacromolecules play a fundamental role in almost all bioprocesses occuring in living organisms. The binding of ligands can cause the conformational changes of biomacromolecules, possibly affecting their physiological functions. The interactions of ligands with biomacromolecules are thus becoming a research hotspot. However, till now, there still lacks a systematic compilation of review with the focus on the interactions between environmental chemicals and biomacromolecules. In this review, we focus on the molecular recognition paradigm of environmental chemicals with biomacromolecules and chemical basis for driving the complex formation. The state-of-the-art review on in vitro and in silico studies on interaction of organic chemicals with transport proteins, nuclear receptors and CYP450 enzymes was provided, and the enantioselective interactions of chiral environmental chemicals was also mentioned.

Keywords: Binding, biomacromolecules, enantionselectivity, interaction, ligand.

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Article Details

Year: 2017
Published on: 09 November, 2016
Page: [41 - 47]
Pages: 7
DOI: 10.2174/1389203717666160421152301
Price: $65

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