Abstract
The effects of non-thermal intensity of microwave (NT MW)- treated physiological solutions (PS) on muscle contractility, 45Ca uptake by muscle and muscle hydration of snail isolated heart in normal and K+-free PS were studied. The intra-cordial perfusion by NT MW-treated PS led to inhibition of heart beating with gradual decrease of the amplitudes of muscle contraction, the weakness of the Na+/K+ pump-induced transient inhibition of heart beating (TIHB), the inhibition of 45Ca2+ uptake by muscle, the increase of intracellular cGMP contents and muscle dehydration. The obtained data serve as additional evidence for hypothesis that cell bathing aqua solution is a primary target for non-thermal effect of MW on cells and organisms.
Keywords: Non-thermal, MW, Heart muscle, Intracellular Ca2+, cGMP, Muscle hydration.
Current Chemical Biology
Title:The Effect of Non-Thermal Microwave-Treated Physiological Solution on Isolated Heart Muscle of Snail
Volume: 10 Issue: 1
Author(s): Gayane Ayrapetyan, Hovik Hayrapetyan and Sinerik Ayrapetyan
Affiliation:
Keywords: Non-thermal, MW, Heart muscle, Intracellular Ca2+, cGMP, Muscle hydration.
Abstract: The effects of non-thermal intensity of microwave (NT MW)- treated physiological solutions (PS) on muscle contractility, 45Ca uptake by muscle and muscle hydration of snail isolated heart in normal and K+-free PS were studied. The intra-cordial perfusion by NT MW-treated PS led to inhibition of heart beating with gradual decrease of the amplitudes of muscle contraction, the weakness of the Na+/K+ pump-induced transient inhibition of heart beating (TIHB), the inhibition of 45Ca2+ uptake by muscle, the increase of intracellular cGMP contents and muscle dehydration. The obtained data serve as additional evidence for hypothesis that cell bathing aqua solution is a primary target for non-thermal effect of MW on cells and organisms.
Export Options
About this article
Cite this article as:
Ayrapetyan Gayane, Hayrapetyan Hovik and Ayrapetyan Sinerik, The Effect of Non-Thermal Microwave-Treated Physiological Solution on Isolated Heart Muscle of Snail, Current Chemical Biology 2016; 10 (1) . https://dx.doi.org/10.2174/2212796810666160419152816
DOI https://dx.doi.org/10.2174/2212796810666160419152816 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pleiotropic Effects of Statin in Therapy in Heart Failure: A Review
Current Vascular Pharmacology Inhibitory Smad7: Emerging Roles in Health and Disease
Current Molecular Pharmacology Biomarkers of Senescence during Aging as Possible Warnings to Use Preventive Measures
Current Medicinal Chemistry Lipid Metabolism and Mitochondria: Cross Talk in Cancer
Current Drug Targets The Discovery and Development of Drug Combinations for the Treatment of Various Diseases from Patent Literature (1980-Present)
Current Topics in Medicinal Chemistry Chlorella vulgaris: A Multifunctional Dietary Supplement with Diverse Medicinal Properties
Current Pharmaceutical Design Targets for Medical Therapy to Limit Abdominal Aortic Aneurysm Progression
Current Drug Targets microRNAs in Cancer: Lessons from Melanoma
Current Pharmaceutical Design Diabetic Vascular Complications: Pathophysiology, Biochemical Basis and Potential Therapeutic Strategy
Current Pharmaceutical Design Is There a Genetic Susceptibility to Bronchopulmonary Dysplasia?
Current Respiratory Medicine Reviews PET Radioligands for In Vivo Visualization of Neuroinflammation
Current Pharmaceutical Design Atherosclerotic Renal Artery Stenosis: An Update on Diagnosis and Management
Current Vascular Pharmacology Management of Primary Aldosteronism: Its Complications and Their Outcomes After Treatment
Current Vascular Pharmacology Novel Oral Anticoagulants in the Treatment of Acute Coronary Syndromes: Is there any Room for New Anticoagulants?
Current Clinical Pharmacology Inhibition of Matrix Metalloproteinases (MMPs) as a Potential Strategy to Ameliorate Hypertension-Induced Cardiovascular Alterations
Current Drug Targets Interstitial Lung Disease in Systemic Sclerosis: Pathophysiology, Current and New Advances in Therapy
Inflammation & Allergy - Drug Targets (Discontinued) Static Cerebral Blood Flow Autoregulation in Humans
Current Hypertension Reviews Novel Ventricular Fibrillation/Tachycardia Detection Algorithms Used for Automated External Defibrillators
Recent Patents on Engineering Inhibition of PI3K/Akt Signaling: An Emerging Paradigm for Targeted Cancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Neurologic and Cardiovascular Complications in Pediatric Life Threatening Imipramine Poisoning
Current Drug Safety