The Effect of Non-Thermal Microwave-Treated Physiological Solution on Isolated Heart Muscle of Snail

Author(s): Gayane Ayrapetyan, Hovik Hayrapetyan, Sinerik Ayrapetyan

Journal Name: Current Chemical Biology

Volume 10 , Issue 1 , 2016


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Abstract:

The effects of non-thermal intensity of microwave (NT MW)- treated physiological solutions (PS) on muscle contractility, 45Ca uptake by muscle and muscle hydration of snail isolated heart in normal and K+-free PS were studied. The intra-cordial perfusion by NT MW-treated PS led to inhibition of heart beating with gradual decrease of the amplitudes of muscle contraction, the weakness of the Na+/K+ pump-induced transient inhibition of heart beating (TIHB), the inhibition of 45Ca2+ uptake by muscle, the increase of intracellular cGMP contents and muscle dehydration. The obtained data serve as additional evidence for hypothesis that cell bathing aqua solution is a primary target for non-thermal effect of MW on cells and organisms.

Keywords: Non-thermal, MW, Heart muscle, Intracellular Ca2+, cGMP, Muscle hydration.

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Article Details

VOLUME: 10
ISSUE: 1
Year: 2016
Page: [2 - 8]
Pages: 7
DOI: 10.2174/2212796810666160419152816
Price: $25

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