Skeletal muscle contractions and their attendant increase in metabolism accelerate production and accumulation
of multiple metabolites in the cytoplasm, interstitium and vascular compartments. Continued myocyte contractile function
and subsequent recovery is often highly dependent upon constraining metabolite accumulation. In particular, the control
of pH ([H+]) during exercise is absolutely crucial for muscle force maintenance and metabolic regulation. This short review
focuses attention on the dynamic control mechanisms that help regulate H+ and thus intramyocyte pH (pHi) during
muscle contractions: Specifically 1. Myocyte H+ production and intrinsic buffering systems, 2. Mechanisms of myocyte
H+ excretion, and 3. Inter-relationships among the intramyocyte - interstitial – blood [H+].
Keywords: Skeletal muscle, pH regulation, Bioimaging, Fatigue, Mitochondria, Fluorescence indicator, Membrane transporter.
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