pH Homeostasis in Contracting and Recovering Skeletal Muscle: Integrated Function of the Microcirculation with the Interstitium and Intramyocyte Milieu

Author(s): Yoshinori Tanaka, David C. Poole, Yutaka Kano

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 24 , 2016


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Abstract:

Skeletal muscle contractions and their attendant increase in metabolism accelerate production and accumulation of multiple metabolites in the cytoplasm, interstitium and vascular compartments. Continued myocyte contractile function and subsequent recovery is often highly dependent upon constraining metabolite accumulation. In particular, the control of pH ([H+]) during exercise is absolutely crucial for muscle force maintenance and metabolic regulation. This short review focuses attention on the dynamic control mechanisms that help regulate H+ and thus intramyocyte pH (pHi) during muscle contractions: Specifically 1. Myocyte H+ production and intrinsic buffering systems, 2. Mechanisms of myocyte H+ excretion, and 3. Inter-relationships among the intramyocyte - interstitial – blood [H+].

Keywords: Skeletal muscle, pH regulation, Bioimaging, Fatigue, Mitochondria, Fluorescence indicator, Membrane transporter.

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Article Details

VOLUME: 16
ISSUE: 24
Year: 2016
Published on: 01 August, 2016
Page: [2656 - 2663]
Pages: 8
DOI: 10.2174/1568026616666160413130221
Price: $65

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