The histamine H4 receptor has stood out since its discovery and
identification in 2000 as an important target in the search for potential new
drugs for the treatment of inflammatory and allergic diseases such as rhinitis,
pruritus and asthma. Thus, in the last decade, both industry and academia
have performed an intensive and productive search for new ligands
of this newest subtype of histamine receptor. The most promising compounds
found include monocyclic and fused azines, and azoles such as
bispyrimidines, di- and triaminopyrimidines, quinazolines, imidazoles, indoles,
benzimidazoles and benzazoles. The aim of this review is to give an
insight into the current state of the art in the field of histamine H4 receptor
research, focusing mainly on the last five years.
Keywords: Histamine H4 receptor, GPCR, indolecarboxamides, benzimidazoles, azines, histamine.
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