Pharmacological Effects of Niacin on Acute Hyperlipemia

Author(s): Sergio Montserrat-de la Paz, Beatriz Bermudez, M. Carmen Naranjo, Sergio Lopez, Rocio Abia, Francisco J.G. Muriana.

Journal Name: Current Medicinal Chemistry

Volume 23 , Issue 25 , 2016

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The well-known changes in modern lifestyle habits including over nutrition and physical inactivity have led to striking adverse effects on public health (e.g., obesity, diabetes, and metabolic syndrome) over recent decades. One noticeable consequence is exaggerated and prolonged state of postprandial hyperlipemia due to the ingestion of multiple fat-enriched meals during the course of a day. Postprandial (non-fasting) hyperlipemia is characterized by increased blood levels of exogenous triglycerides (TG) in the form of apolipoprotein (apo) B48-containing TG-rich lipoproteins (TRL), which have a causal role in the pathogenesis and progression of cardiovascular disease (CVD). The cardiovascular benefits of lifestyle modification (healthy diet and exercise) and conventional lipid-lowering therapies (e.g., statins, fibrates, and niacin) could involve their favourable effects on postprandial metabolism. Pharmacologically, niacin has been used as an athero-protective drug for five decades. Studies have since shown that niacin may decrease fasting levels of plasma verylow- density lipoproteins (VLDL), low-density lipoprotein cholesterol (LDL-C), and lipoprotein [a] (Lp[a]), while may increase high-density lipoprotein cholesterol (HDL-C). Herein, the purpose of this review was to provide an update on effects and mechanisms related to the pharmacological actions of niacin on acute hyperlipemia.

Keywords: Niacin, Vitamin B3, Hyperlipemia, Triglyceride-rich lipoproteins, Postprandial state, Cardiovascular disease.

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Article Details

Year: 2016
Page: [2826 - 2835]
Pages: 10
DOI: 10.2174/0929867323666160411142909
Price: $65

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