Effect of Microenvironment Modulation on Stem Cell Therapy for Peripheral Nerve Injury
Pp. 190-224 (35)
Sufang Liu and Feng Tao
Previous studies have demonstrated that nerve damage results in rapid
disruption of nerve function. Neural stem cells (NSCs) from spinal cord have been
shown to promote peripheral nerve regeneration. However, the stem cell therapy still
shows low efficiency in vivo and some miscommunications after nerve recovery. Our
studies found that chemotactic factor stromal-cell derived factor 1α and hypoxia may
improve the survival of the transplanted NSCs and their function. Here we discuss the
effects of microenvironment on neural stem cell therapy for peripheral nerve injury and
recent progresses in this research field.
Hypoxia, microenvironment, Neural stem cells, neurotrophic factor,
pain, Peripheral nerve injury, Stromal cell derived factor.
Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, Texas, USA.