Differentiation Potential of Stem Cells into Ovarian Cells
Pp. 116-156 (41)
Derek Toms, Paul W. Dyce and Julang Li
The following chapter outlines the current research status of studies
exploring the generation of two essential ovarian cell types from stem cells: meiotic
female germ cells from primordial germ cells to oocytes; and supporting somatic
granulosa cells that are necessary for correct germ cell development and sex hormone
production. Recent studies have reported the generation of both cell types in vitro and in
vivo from a variety of sources, including somatic stem cells, induced pluripotent stem
cells, and embryonic stem cells. While significant progress has been demonstrated,
there are many areas that require further investigation. This review also discusses
current research limitations and future prospects of this field within the context of
Differentiation, follicle, folliculogenesis, granulosa cell, meiosis,
oocyte, ovary, stem cells.
Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada.