Biological and Therapeutic Implications of Cancer Stem Cells
Pp. 63-101 (39)
Ruth M. Risueño, Amaia Etxabe and Josep Maria Cornet-Masana
Cancer stem cells (CSCs) are a subset of cells within a tumor having selfrenewal
and differentiation capacity. Due to their “stem cell”-like properties, CSCs are
thought to be responsible for cancer initiation, progression, metastasis, recurrence and
drug resistance. Thus, therapeutic strategies that focus on targeting CSCs and their
microenvironmental niche address the ineffectiveness of traditional cancer therapies to
eradicate the CSCs that otherwise result in therapy resistance. Over the past years, a
great effort has been invested in the development of new compounds and repositioning
of already approved drugs that selectively target CSCs, some of which have been
evaluated in preclinical and clinical studies.
Adult stem cell, biomarker, cancer model, cancer stem cell, clinical
trial, development, differentiation, drug discovery, embryonic stem cell, Hh,
microenvironment, new therapeutic approach, Notch, regeneration, self-renewal,
therapeutic target, tumor, tumorigenesis, Wnt, xenotransplantation.
Josep Carreras Leukaemia Research Institute, Barcelona, Spain.