Abstract
A new generation of natural phosphate-supported palladium was synthesized by treating natural phosphate with bis(benzonitrile)palladium(II) chloride in acetone. Its catalytic activity was evaluated in selective hydration of nitriles. The reactions proceeded in the presence of 0.4 mol% of the palladium catalyst at 160°C in water under microwave irradiation. Several nitriles, including aromatic and heteroaromatic nitriles, were converted to corresponding amides in good yields under neutral conditions. The recyclability and low cost availability of this solid support make this approach very attractive. It encourages new fields of research in the valorization of this natural resource and can change the current view of heterogeneous catalysis.
Keywords: Natural phosphate, supported-Pd catalyst, microwave irradiation, selective hydration, amides, green chemistry.
Current Organic Chemistry
Title:Natural Phosphate-Supported Palladium for Hydration of Aromatic Nitriles to Amides in Aqueous Medium
Volume: 20 Issue: 19
Author(s): Ayoub Hassine, Saïd Sebti, Abderrahim Solhy, Nicolas Thiebault, Bilal Essaid, Christophe Len and Aziz Fihri
Affiliation:
Keywords: Natural phosphate, supported-Pd catalyst, microwave irradiation, selective hydration, amides, green chemistry.
Abstract: A new generation of natural phosphate-supported palladium was synthesized by treating natural phosphate with bis(benzonitrile)palladium(II) chloride in acetone. Its catalytic activity was evaluated in selective hydration of nitriles. The reactions proceeded in the presence of 0.4 mol% of the palladium catalyst at 160°C in water under microwave irradiation. Several nitriles, including aromatic and heteroaromatic nitriles, were converted to corresponding amides in good yields under neutral conditions. The recyclability and low cost availability of this solid support make this approach very attractive. It encourages new fields of research in the valorization of this natural resource and can change the current view of heterogeneous catalysis.
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Cite this article as:
Hassine Ayoub, Sebti Saïd, Solhy Abderrahim, Thiebault Nicolas, Essaid Bilal, Len Christophe and Fihri Aziz, Natural Phosphate-Supported Palladium for Hydration of Aromatic Nitriles to Amides in Aqueous Medium, Current Organic Chemistry 2016; 20 (19) . https://dx.doi.org/10.2174/1385272820666160407154559
DOI https://dx.doi.org/10.2174/1385272820666160407154559 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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