The worldwide increasing prevalence of obesity and sedentary lifestyle is the main cause
of the rising incidence of T2DM. Due to chronic macrovascular and microvascular complications,
T2DM represent a huge socioeconomic burden in the world. Oxidative stress is a key pathogenic
mechanism implicated in diabetic coronary artery disease (CAD). Polymorphisms of oxidative stress
genes are known to influence oxidative stress levels and are therefore thought to impact CAD
pathogenesis. Identifying higher risk groups would be rational, since it would allow better sample
selection and thus better results in antioxidant trials. In this review, we summarize the evidence of
oxidative stress gene polymorphisms related to the pathogenesis of CAD. Moreover, we provide a review of antioxidants
tested in subjects with CAD.
Keywords: Antioxidants, coronary artery disease, diabetes mellitus, insulin, obesity, oxidative stress.
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