Therapeutic Indications and Action Mechanisms of Bilirubin: Suggestions from Natural Calculus Bovis

Author(s): Jijun Chen, Aiqin Wang, Qingqi Chen

Journal Name: Current Signal Transduction Therapy

Volume 11 , Issue 1 , 2016

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


As a pathological product of bovine gallbladder, natural Calculus Bovis (CB) has a long history in Traditional Chinese Medicine to treat many diseases such as: stroke,coma, delirium, epilepsy, encephalitis B, etc. Experimental studies showed that natural CB had effects on central nervous system, cardiovascular system, inflammation, etc. Recent analyses confirmed that bilirubin composed the main proportion of all CB components. Preclinical researches demonstrated that bilirubin had ischemia protection, antiinflammation, anti-cancer, anti-virus, erythropoiesis, anti-pyretic, immune function protection, and cardiovascular effects. Mechanism investigations indicated bilirubin as a powerful antioxidant. Bilirubin also inhibited inflammatory factors and complement. Here, we suggest bilirubin may account for many effects of CB, and has potential therapeutic prospects.

Keywords: Antioxidant, bilirubin, biliverdin, heme oxygenase, natural Calculus Bovis, therapeutic.

promotion: free to download

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Published on: 20 June, 2016
Page: [13 - 22]
Pages: 10
DOI: 10.2174/1574362411666160407212127

Article Metrics

PDF: 36