Objective: The aim of this study was to fabricate the composite of poly(4-vinylpyridine)
(P4VP) with rubidium metal salt to improve polymeric properties including thermal stability as well as
the pathogen and enzyme inhibition activity.
Methods: The composites were synthesized via sol gel technique. The resulting product was studied
through various analytical techniques including fourier transform infrared spectroscopy, x-ray diffractometry
(XRD), thermal gravimetric analysis (TGA), differential thermal analysis (DTA) and differential
scanning calorimetry (DSC). Bioactivity of the rubidium chloride/polymer matrix composite (RbCl-PMC)
was assessed by performing different bioassays like antioxidant activity (DPPH radical scavenging activity),
anti-microbial activity (antifungal and antibacterial), enzyme inhibition activity against protein
kinase and α-amylase enzymes and cytotoxicity by Brine Shrimp method.
Results: The XRD data depicts that the amorphous nature of polymer is reduced by incorporating rubidium
chloride and the resulting composite is well crystalline in nature. Grain size, strain, dislocation line
density, molecular packing in crystal lattice (face-centered cubic), unit cell structure, Bravia’s lattice parameters,
and the volume of the unit cell were determined from XRD data, while, thermal degradation
pattern illustrates that thermal stability of the synthesized composite enhanced as compared to P4VP.
Moreover, P4VP-rubidium chloride composite exhibited good antioxidant, antibacterial, and cytotoxic
Conclusion: P4VP-rubidium chloride composite is found to be an active pharmaceutical.