Bioactivities of Rubidium Chloride-Poly (4-Vinylpyridine) Composite Fabricated Via Sol Gel Technique

Author(s): Rehana Rashid, Sadullah Mir, Majid Hussain, Atiya Zahra, Ghulam Murtaza*, Ihsan ul Haq, Saqib Ali, Abida Kalsoom Khan*

Journal Name: Current Pharmaceutical Analysis

Volume 13 , Issue 3 , 2017


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Abstract:

Objective: The aim of this study was to fabricate the composite of poly(4-vinylpyridine) (P4VP) with rubidium metal salt to improve polymeric properties including thermal stability as well as the pathogen and enzyme inhibition activity.

Methods: The composites were synthesized via sol gel technique. The resulting product was studied through various analytical techniques including fourier transform infrared spectroscopy, x-ray diffractometry (XRD), thermal gravimetric analysis (TGA), differential thermal analysis (DTA) and differential scanning calorimetry (DSC). Bioactivity of the rubidium chloride/polymer matrix composite (RbCl-PMC) was assessed by performing different bioassays like antioxidant activity (DPPH radical scavenging activity), anti-microbial activity (antifungal and antibacterial), enzyme inhibition activity against protein kinase and α-amylase enzymes and cytotoxicity by Brine Shrimp method.

Results: The XRD data depicts that the amorphous nature of polymer is reduced by incorporating rubidium chloride and the resulting composite is well crystalline in nature. Grain size, strain, dislocation line density, molecular packing in crystal lattice (face-centered cubic), unit cell structure, Bravia’s lattice parameters, and the volume of the unit cell were determined from XRD data, while, thermal degradation pattern illustrates that thermal stability of the synthesized composite enhanced as compared to P4VP. Moreover, P4VP-rubidium chloride composite exhibited good antioxidant, antibacterial, and cytotoxic activities.

Conclusion: P4VP-rubidium chloride composite is found to be an active pharmaceutical.

Keywords: Poly(4-vinylpyridine) composite, rubidium chloride, FTIR, XRD, thermal studies, biocompatible behavior of RbCl-PMC.

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2017
Published on: 05 April, 2017
Page: [256 - 263]
Pages: 8
DOI: 10.2174/1573412912666160407123310
Price: $65

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