Synthesis and Biological Activity of 3-(substitutedphenyl)- 6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

Author(s): Niranjan Kaushik, Nitin Kumar, Anoop Kumar

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
(Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents)

Volume 16 , Issue 1 , 2016

Graphical Abstract:


A new series of triazole containing thiadiazine moiety have been synthesized and characterized. All the new compounds were assayed for their in vitro antioxidant activity by DPPH free radical scavenging method and in vivo anti-diabetic activity by streptozotocin-induced model in albino rat. Anticancer activity of synthesized compounds was performed at the National Cancer Institute (NCI) on NCI 60 cell lines panel. Among the synthesized compounds, 2d exhibited more prominent antioxidant activity with IC50 value 16.97 g/ml, 59.15% blood glucose lowering activity and moderate anticancer activity with 44.59% growth inhibition against CCRF-CEM (Leukemia) cell lines. Compounds 2e and 2j showed good antioxidant activity with IC50 value 21.40 and 18.78 g/ml. Compounds 2b and 2e showed significant 59.98 and 48.44% blood glucose lowering activity.

Keywords: Anticancer activity, anti-diabetic activity, antioxidant activity, streptozotocin, thiadiazine, thiocarbohydrazide, triazole.

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Article Details

Year: 2016
Page: [70 - 80]
Pages: 11
DOI: 10.2174/1871522216999160406125836
Price: $58

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