Abstract
Background: Hyperstructures are large assemblies of molecules and macromolecules that perform functions such as metabolism (including RNA and protein synthesis and degradation), transport, DNA replication, cell division, signalling and chemotaxis.
Methods: Such hyperstructures might be manipulated by hybrid metabolites or hybolites made by a pairwise, covalently linked combination of the thousands of small molecules involved in metabolism and signalling.
Results: Here, we review recent evidence for hyperstructures in prokaryotes and for interactions between hyperstructures as a determinant of the phenotype.
We also mention extending hybolite therapy to eukaryotes, consider new designs for hybolites, and discuss relevant patents.
Keywords: Antibiotic, cancer, infection, macromolecular assembly, pathogen, polyphosphate.
Graphical Abstract
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Current Bioactive Compounds
Current Drug Safety
Current Drug Targets
Current Medicinal Chemistry
Current Pharmaceutical Biotechnology
Central Nervous System Agents in Medicinal Chemistry
Infectious Disorders - Drug Targets
Letters in Drug Design & Discovery
Current HIV Research
Related Books
Marine Biopharmaceuticals: Scope and Prospects
COVID 19 – Monitoring with IoT Devices
Frontiers in Clinical Drug Research: Anti-Infectives
Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19
Recent Advances in the Application of Marine Natural Products as Antimicrobial Agents
Recent Trends and The Future of Antimicrobial Agents - Part 2
COVID-19: Origin, Impact and Management (Part 2)
Frontiers in Anti-Infective Drug Discovery
COVID-19: Origin, Impact and Management, Part 1
Toll-Like Receptors in Vector-borne Diseases
22
1