Hybolites Revisited

Author(s): Victor Norris, Cecile Verrier, Marc Feuilloley

Journal Name: Recent Patents on Anti-Infective Drug Discovery
Continued as Recent Advances in Anti-Infective Drug Discovery

Volume 11 , Issue 1 , 2016


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Graphical Abstract:


Abstract:

Background: Hyperstructures are large assemblies of molecules and macromolecules that perform functions such as metabolism (including RNA and protein synthesis and degradation), transport, DNA replication, cell division, signalling and chemotaxis.

Methods: Such hyperstructures might be manipulated by hybrid metabolites or hybolites made by a pairwise, covalently linked combination of the thousands of small molecules involved in metabolism and signalling.

Results: Here, we review recent evidence for hyperstructures in prokaryotes and for interactions between hyperstructures as a determinant of the phenotype.

We also mention extending hybolite therapy to eukaryotes, consider new designs for hybolites, and discuss relevant patents.

Keywords: Antibiotic, cancer, infection, macromolecular assembly, pathogen, polyphosphate.

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2016
Published on: 06 April, 2016
Page: [16 - 31]
Pages: 16
DOI: 10.2174/1574891X11666160406121706

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