Title:Anticancer Drug Combinations, How Far We can Go Through?
VOLUME: 17 ISSUE: 1
Author(s):Da-Yong Lu, En-Hong Chen, Hong-Ying Wu, Ting-Ren Lu, Bin Xu and Jian Ding
Affiliation:School of Life Sciences, Shanghai University, Shanghai200444, PR China.
Keywords:Drug combination, drug resistance, neoplasm metastasis, biotherapy, cancer stem cell, personalized cancer therapy.
Abstract:Many clinical cancer therapies are less effective by using one anticancer drug only due to refractory
properties of cancer pathogenesis and drug resistance property in advanced cancer patients. A general consensus
among clinicians is that anticancer drug cocktail might better control cancer progresses and metastasis than single drug
therapeutics in clinical trials. Despite great popularity, the anticancer drug combination dogma has not been
established. The complexity of drug combination dogma discovery is more than we can expect now. This article
speculates possible routes we can undertake in this matter. The background knowledge of drug combination therapy
presently practiced and possible future landscapes and drawbacks of cancer drug combinative therapies are
highlighted.
