Title:Acethylcholinesterase Inhibition, Antibacterial and Antioxidant Properties of Diaryl Oxalates
VOLUME: 13 ISSUE: 1
Author(s):Gunay K. Kantar, Nimet Baltaş*, Fatih Ş. Beriş and Selami Şaşmaz
Affiliation:Recep Tayyip Erdogan University, Science and Art faculty, Chemistry Department, Rize, 53100, Recep Tayyip Erdogan University, Science and Art faculty, Chemistry Department, Rize, 53100, Recep Tayyip Erdogan University, Science and Art faculty, Biology Department, Rize, 53100, Recep Tayyip Erdogan University, Science and Art faculty, Chemistry Department, Rize, 53100
Keywords:Anti-acetylcholinesterase, antimicrobial, antioxidant, diaryl oxalate.
Abstract:Objective: The main study was to synthesize the diaryl oxalates containing
pharmacophore groups like eugenol and guaiacol moieties, investigate antioxidant,
antibacterial and acethylcholinesterase inhibitory properties and compare with
each other.
Method: The compounds were screened for their antioxidant properties by
employing three in vitro assays like CUPric Reducing Antioxidant Capacity
(CUPRAC) and 2,2-Diphenyl-1-Picrylhydrazyl (DPPH•) radical scavenging assay,
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS•+) assay and they exhibited
very promising results. Also, The compounds were evaluated for their antiacetylcholinesterase
activity (anti-AChE) and anti-microbial effects against Bacillus
subtilis ATCC 6633, S. pyogenes ATCC 19615, Y. pseudotuberculosis ATCC 911, E. cloaceae ATCC
25923, and E. coli ATCC 25922.
Results: The compounds were found to possess good antioxidant (TEAC values:7.834-9.353 mM
TEAC/mg compound) and inhibitiory activity against AChE (IC50=11.95±0.27 for compound 2). Antimicrobial
activity results show that compound 1 has the same antimicrobial effect on the bacteria in
this study and is more effective than compound 2.
Conclusion: The results indicate that these compounds have not only good antioxidant and antimicrobial
activity, but is also a powerful AChE inhibitors.
