Research has been lately prospering in the field of Janus nanoparticles, focusing on new
synthesis techniques and their application in various fields. This is due to the unique characteristics
possessed by this type of particles such as their anisotropic nature, and their synergistic potential for
combination therapy in addition to the multilevel targeting. These unique features are essential in several
biomedical applications, especially the controlled drug delivery. Various techniques have been
used for the synthesis of Janus nanoparticles including; masking, self-assembly, microfluidic and
phase separation. They are all aiming at production of uniformly sized Janus particles with spatially
separated functionalities. Herein, the main synthesis approaches of various Janus nanoparticles are briefly reviewed with
the provision of examples of studies focusing on the potential applications of Janus particles in controlled drug delivery.
Keywords: Janus, nanoparticles, nanocapsules, nanomotors, microfluidic, drug delivery.
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