In this non-comprehensive review a selection of tandem processes combining
sigmatropic rearrangement with Diels–Alder reactions is presented. The synthetic utility of
these two transformations is indisputable as they can lead to complex natural products in an
efficient and selective way. Most of the examples presented here have been chosen in view
of their application to natural products synthesis. The emphasis of the discussion is put on
the illustration of new strategic disconnections becoming accessible thanks to tandem processes.
Keywords: Diels–Alder, cycloaddition, sigmatropic rearrangements, tandem cascade, tactical combination, retrosynthesis.
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