Background: This manuscript addresses the multilevel role of dietary nitrate and nitrite in
health and diseases because of increased interest in dietary supplementation.
Method: Review of research devoted to both beneficial but also possible deleterious effects of
uncontrolled indigestion of red beet-root juice and other sources of high concentrated nitrate and nitrite.
Results: The body of evidence strongly suggested that persons using nitrate/nitrite supplementation
and particularly patients treated with sodium nitrite, having kidney disease or impaired
methemoglobin reeducates activity, should closely monitor nitrate/nitrite indigestion.
Conclusion: Oral intake of red beet-root juice, green leaved veggies, cured meat, as well as urine excretion of nitrate/
nitrite, methemoglobin reeducates activity should be carefully assessed especially in patients treated with sodium nitrite.