Uterine Cervical Neurotransmission and Cervical Remodeling

Author(s): Chishimba N. Mowa

Journal Name: Current Protein & Peptide Science

Volume 18 , Issue 2 , 2017

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Graphical Abstract:


Cervical remodeling (CR) is a complex process, which, in part, is believed to be induced by physiological inflammation. Even though the female reproductive tissues are richly innervated by nerves from the parasympathetic pelvic autonomic ganglia, sensory dorsal root and nodose ganglia, their roles (neuronal factors) in this process (CR) has been largely attributed to sex steroid hormones, until recently. Here, we discuss the interaction between neuropeptides derived from peripheral nerves associated with uterine cervix and estrogen, and their likely impact on cervical remodeling. It is likely that these neuronal factors, under the influence of estrogen, could induce physiological inflammation during cervical remodeling by promoting the expression of vascular endothelial growth factor, among other factors.

Keywords: Cervix, cervical remodeling, innervation, neuropeptides, vascular endothelial growth factor (VEGF).

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Article Details

Year: 2017
Published on: 13 December, 2016
Page: [120 - 124]
Pages: 5
DOI: 10.2174/1389203717666160322150224
Price: $65

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