Cervical remodeling (CR) is a complex process, which, in part, is believed to be induced by
physiological inflammation. Even though the female reproductive tissues are richly innervated by nerves
from the parasympathetic pelvic autonomic ganglia, sensory dorsal root and nodose ganglia, their roles
(neuronal factors) in this process (CR) has been largely attributed to sex steroid hormones, until recently.
Here, we discuss the interaction between neuropeptides derived from peripheral nerves associated with
uterine cervix and estrogen, and their likely impact on cervical remodeling. It is likely that these neuronal
factors, under the influence of estrogen, could induce physiological inflammation during cervical remodeling
by promoting the expression of vascular endothelial growth factor, among other factors.