Title:Biological Rationale for Regular Physical Exercise as an Effective Intervention for the Prevention and Treatment of Depressive Disorders
VOLUME: 22 ISSUE: 24
Author(s):Helios Pareja-Galeano, Sara Mayero, María Perales, Nuria Garatachea, Alejandro Santos-Lozano, Carmen Fiuza-Luces, Enzo Emanuele, Beatriz G. Gálvez, Fabian Sanchis-Gomar and Alejandro Lucia
Affiliation:Research Institute of the Hospital 12 de Octubre (‘i+12’) 6th Floor, Laboratories Sector, CAA Building Avda. de Córdoba s/n, 28041, Madrid, Spain
Keywords:Major depression, physical activity, neurogenesis, brain-derived neurotrophic factor, serotonin, antidepressant.
Abstract:Depression is a major medical and social problem. Here we review current body of knowledge on the
benefits of exercise as an effective strategy for both the prevention and treatment of this condition. We also analyze
the biological pathways involved in such potential benefits, which include changes in neurotrophic factors, oxidative
stress and inflammation, telomere length, brain volume and microvessels, neurotransmitters or hormones. We
also identify major caveats in this field of research: further studies are needed to identify which are the most appropriate types of exercise
interventions (intensity, duration, or frequency) to treat and prevent depression.
