Background: The present study is aimed at bringing out the information on the effect of
berberine chloride in hyper and hypo thyroidal model with two dose levels.
Objective: The research article also reviewed details of various existing patents associated with comprehensive
compilation regarding the therapeutic application of berberine and related forms.
Method: Sixty female wistar rats weighing between 150-250 gm were divided in to 10 groups. The
animals were grouped in to solvent control; hypothyroid; hyperthyroid; prophylactic with two different doses of berberine
chloride (50 and 100 mg/kg); treatment groups similar to that of the prophylactic and therapeutic group. To substantiate
the dose dependent effect of berberine chloride in 6-n-propyL-2-thiouracil (PTU) induced hypothyroidism, lipid profile,
thyroid profile, enzymes profiles and blood profiles, in addition to histopathological studies were also carried out. There
was no any significant difference in the lipid profile among solvent control, treatment and prophylactic groups. However,
there was a significant difference (***p<0.001) in serum triglycerides, LDL and VLDL of hypothyroid group when compound
to that of the rest.
Results: As far as thyroid profile is concerned, T3 level of berberine chloride (50 mg/kg) treated groups (prophylactic+
treatment) showed a significant rise compared to hypothyroid group. TSH level in prophylactic groups was far higher
than the rest of the groups (3.002±0.0192, 1.051±0.0008 against the solvent control, 0.308±0.008). SGOT, SGPT levels
were significantly higher with the therapeutic group than that of the normal and hypo-thyroidal group. Blood profile of
berberine chloride (100 mg/kg) treated therapeutic group was comparable to that of the solvent control than all other
groups. The probable mechanism underlying may be that inactivation of type I 5-iodothyronine deiodinase (5DI) enzyme
by NF-κB pathway.
Conclusion: From the findings of the current study it can be concluded that berberine chloride possesses both thyroid
stimulating and suppressing activities depending on its dose, especially berberine chloride 50 mg/kg supports thyroid