Tissue hypoxia may occur in many diseases, specifically during the occurrence
and growth of malignant solid-tumors. Targeting hypoxia is one of the most significant characteristics
of tumors in diagnosis, monitoring, and treatment. This review summarizes the
current oxygen-sensitive imaging agents used to target tumor hypoxia, including positron-emission computed
tomography/single photon-emission computed tomography radionuclide labeled tracers, magnetic resonance
imaging contrast agents for hypoxia detection, and hypoxia-sensitive optical imaging probes. Researchers
have utilized nanotechnology as a useful toolkit to improve the effects of oxygen-sensitive imaging agents.
We emphasize the progress and influence of nanotechnology in these materials and technologies. This review
demonstrates that hypoxia imaging agents have promising prospects, and may provide helpful information for
tumor diagnosis and prognosis.
Keywords: Imaging agents, magnetic resonance, optical imaging, oxygen sensing, radiology, tumor hypoxia.
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