Neuroinflammation and Immunity: A New Pharmacological Target in Depression

Author(s): Rosalia Crupi, Salvatore Cuzzocrea

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 15 , Issue 4 , 2016

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Major depressive disorder (MDD) is a debilitating illness that affects a significant percentage of the world population. This disorder is associated with diminshed productivity and reduced quality of life; unfortunately the underlying pathophysiological mechanisms are not fully clarified. Recently, several studies have suggested that psychiatric disorders could be considered as inflammatory disorders; nevertheless.. Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factorsThere is strong evidence that depression involves alterations in multiple aspects of immunity that may contribute to the development or exacerbation of a number of medical disorders and also may play a role in the pathophysiology of depressive symptoms.

This review highlights the role of neuroinflammation and immunity in the pathophysiology of psychiatric disorders such as MDD.

Keywords: Immunity, major depressive disorder, neuroinflammation.

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Article Details

Year: 2016
Published on: 28 March, 2016
Page: [464 - 476]
Pages: 13
DOI: 10.2174/1871527315666160321105339
Price: $65

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