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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Progress in Research of KV1.1 and KV1.3 Channels as Therapeutic Targets

Author(s): Wei Zhao and Yuan Chen

Volume 16, Issue 16, 2016

Page: [1877 - 1885] Pages: 9

DOI: 10.2174/1568026616666160315142920

Price: $65

Abstract

Voltage-gated potassium channels (KV) mainly response in action potential repolarization in excitable cells and also participate in regulating resting potentials in non-excitable cells, involved in diverse physiological processes. This review focuses on potential drug developments targeting the KV1.1 and KV1.3 channels. KV1.1 mainly existing in the nervous system plays key roles in controlling neuronal excitability; while the distribution of KV1.3 in different types of cells contributes to a variety of cellular processes. This article seeks to review the distributions of two channels, their roles in diseases, phenotypes of knockout mice, human channelopathies and selective modulators.

Keywords: Autoimmune disease, channel blocker, KV1.1, KV1.3, potassium channel, toxin.

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