Abstract
Voltage-gated potassium channels (KV) mainly response in action potential repolarization in excitable cells and also participate in regulating resting potentials in non-excitable cells, involved in diverse physiological processes. This review focuses on potential drug developments targeting the KV1.1 and KV1.3 channels. KV1.1 mainly existing in the nervous system plays key roles in controlling neuronal excitability; while the distribution of KV1.3 in different types of cells contributes to a variety of cellular processes. This article seeks to review the distributions of two channels, their roles in diseases, phenotypes of knockout mice, human channelopathies and selective modulators.
Keywords: Autoimmune disease, channel blocker, KV1.1, KV1.3, potassium channel, toxin.
Current Topics in Medicinal Chemistry
Title:Progress in Research of KV1.1 and KV1.3 Channels as Therapeutic Targets
Volume: 16 Issue: 16
Author(s): Wei Zhao and Yuan Chen
Affiliation:
Keywords: Autoimmune disease, channel blocker, KV1.1, KV1.3, potassium channel, toxin.
Abstract: Voltage-gated potassium channels (KV) mainly response in action potential repolarization in excitable cells and also participate in regulating resting potentials in non-excitable cells, involved in diverse physiological processes. This review focuses on potential drug developments targeting the KV1.1 and KV1.3 channels. KV1.1 mainly existing in the nervous system plays key roles in controlling neuronal excitability; while the distribution of KV1.3 in different types of cells contributes to a variety of cellular processes. This article seeks to review the distributions of two channels, their roles in diseases, phenotypes of knockout mice, human channelopathies and selective modulators.
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Cite this article as:
Zhao Wei and Chen Yuan, Progress in Research of KV1.1 and KV1.3 Channels as Therapeutic Targets, Current Topics in Medicinal Chemistry 2016; 16 (16) . https://dx.doi.org/10.2174/1568026616666160315142920
DOI https://dx.doi.org/10.2174/1568026616666160315142920 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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