Voltage-gated potassium channels (KV) mainly response in action potential repolarization in
excitable cells and also participate in regulating resting potentials in non-excitable cells, involved in
diverse physiological processes. This review focuses on potential drug developments targeting the
KV1.1 and KV1.3 channels. KV1.1 mainly existing in the nervous system plays key roles in controlling
neuronal excitability; while the distribution of KV1.3 in different types of cells contributes to a variety
of cellular processes. This article seeks to review the distributions of two channels, their roles in diseases,
phenotypes of knockout mice, human channelopathies and selective modulators.
Keywords: Autoimmune disease, channel blocker, KV1.1, KV1.3, potassium channel, toxin.
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