Bladder cancer is the most prevalent malignancy of the urinary tract and is associated with
significant morbidity and mortality. Preventative efforts to reduce the medical and financial burdens of
bladder cancer are highly desirable. However, the utilization of natural and pharmaceutical products for
the prevention and treatment of bladder cancer remains largely controversial. Herein, we review the
current body of evidence surrounding a number of natural dietary substances and their roles in chemoprevention
of bladder cancer. Possible chemopreventative properties of several pharmaceutical agents
are also reviewed. Overall, the current body of evidence is insufficient to establish a clear link between
these proposed chemopreventive agents and risk of bladder cancer.
Keywords: Bladder cancer, heterogeneous disease, Chemoprevention, DNA, Vitamin D, green tea.
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