Alzheimer’s disease (AD) is currently one of the most studied neurodegenerative
disorders in humans. First reported in 1907, the disease has a familial form
which represents approximately 5% of cases, while the remaining, sporadic cases are
of multifactorial etiology. The disease progression of the latter form has specific
pathological and functional characteristics, which have unknown etiology. Several
authors have proposed a viral etiology for AD, while others implicate many neurotropic
infectious agents. This review compares research findings regarding pathways and effects of neuropathological
viruses with the pathways and effects involved in the progression of AD. The similarities are striking and provide a compelling
argument for a pathogen-based etiology of AD.
Keywords: Alzheimer’s disease, beta amyloid, cell cycle reentry, herpes simplex virus, HSV1, tau pathology.
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